International scientific monitoring

Bioenergetic biomarkers as predictive indicators and their relationship to cognitive function

In newly diagnosed, treatment-naïve patients with bipolar disorder.

Investigators involved: Ting Cao, BAoYan Xu, SuJuan Li, Yan Qiu, JinDong Chen, HaiShan Wu and HaLin Cai.

Publication date: April 14, 2025.

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Variability rather than average?

Exploiting the adversary to advance precision psychiatry.

Researchers involved: Raquel E. Gur, David R. Roalf, Daniel H. Wolf and Ruben C. Gur.

Publication date: April 1, 2025.

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Let's move towards precision suicidology

Researchers involved: Philippe Courtet and P.A Saiz.

Publication date: March 18, 2025.

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Circulating blood proteins in psychopathology and cognition

A Mendelian randomization study.

Researchers involved: Upasana Bhattacharyya, Jibin John, Max Lam, Jonah Fisher, Benjamin Sun, Denis Baird, Stephen Burgess, Chia-Yen Chen and Todd Lencz.

Publication date: March 12, 2025.

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Metabolic syndrome and schizophrenia

Adding a piece to the interaction between the kynurenine pathway and inflammation.

Researchers involved: Jacopo Sapienza, Giulia Agostoni, Federica Repaci, Marco Spangaro, Stefano Comai and Marta Bosia.

Publication date: March 5, 2025.

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Prediction of relapse in a French cohort of outpatients with schizophrenia

Prediction, not association.

Researchers involved: Susana Barbosa, Ryad Tamouza, Marion Leboyer, Bruno Aouizerate, Christelle Andrieu, Myrtille Andre, Wahid Boukouaci, Delphine Capdevielle, Isabelle Chereau, Julie Clauss Kobayashi, Nathalie Coulon, Jean-Michel Dorey, Laetitia Davidovic, Caroline Dubertret, Eric Fakra, Guillaume Fond, Tudi Goze, Olfa Khalfallah, Sylvain Leignier, Pierre Michel Llorca, Jasmina Mallet, Emanuela Martinuzzi, David Misdrahi, Nicolas Oriol, Baptiste Pignon, Romain Rey, Paul Roux, Franck Schürhoff, Benoit Schorr, Mathieu Urbach, Etienne Very, Ching-Lien Wu, Michael Benros, Judit Simon, Alkomiet Hasan, The FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) collaborators, Nicolas Glaichenhaus and Ophélia Godin.

Publication date: February 27, 2025.

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Neurofind: using deep learning to make individualized inferences in brain disorders

Researchers involved: S. Vieira, L. Baecker, W. H. L. Pinaya, R. Garcia-Dias, C. Scarpazza, V. Calhoun and A. Mechelli.

Publication date: February 27, 2025.

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Genetic correlates of treatment-resistant depression

Researchers involved: Bohan Xu, Katherine L. Forthman, Rayus Kuplicki, Jonathan Ahern, Robert Loughnan, Firas Naber, Wesley K. Thompson, Charles B. Nemeroff, Martin P. Paulus and Chun Chieh Fan.

Publication date: February 26, 2025.

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Oxidative and nitrosative stress in bipolar disorder and its familial aggregation

Researchers involved: Singh Harpreet, Singh Abhishek K, Kar, Sujita K, Tripathi Adarsh, Dalal Pronob K and Dikshit Madhu.

Publication date: February 2025.

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Prediction of available drug targets and common genetic links in bipolar disorder and major depressive disorder

Researchers involved: Bin Gong, Chenxu Xiao, Yu Feng and Jing Shen.

Publication date: January 30, 2025.

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Precision psychiatry : thinking beyond simple prediction models

Enhancing causal predictions.

Researchers involved: Rajeev Krishnadas, Samuel P. Leighton and Peter B. Jones.

Publication date: January 15, 2025.

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Assessment and ascertainment in psychiatric molecular genetics

Challenges and opportunities for cross-disorder research.

Researchers involved: Na Cai, Brad Verhulst, Ole A. Andreassen, Jan Buitelaar, Howard J. Edenberg, John M. Hettema, Michael Gandal, Andrew Grotzinger, Katherine Jonas, Phil Lee, Travis T. Mallard, Manuel Mattheisen, Michael C. Neale, John I. Nurnberger Jr, Wouter J. Peyrot, Elliot M. Tucker-Drob, Jordan W. Smoller and Kenneth S. Kendler.

Publication date: December 27, 2024.

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A stratified treatment algorithm in psychiatry

A program on stratified pharmacogenomics in severe mental illness (Psych-STRATA) : concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe.

Researchers involved: B. T. Baune, S. E. Fromme, M. Aberg, M. Adli, A. Afantitis, I. Akkouh, O. A. Andreassen, C. Angulo, S. Barlati, C. Brasso, P. Bucci, M. Budde, P. Buspavanich, V. Cavone, K. Demyttenaere, C. M. Diaz-Caneja, M. Dierssen, S. Djurovic, M. Driessen, U. W. Ebner-Priemer, J. Engelmann, S. Englisch, C. Fabbri, P. Fossati and M. J. Zille.

Publication date: December 27, 2024.

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The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders

A Two-Step Mendelian Randomization Analysis.

Researchers involved: Linlin Zhao, Liwen Tan, Weiqing Liu, Sijie Zhang, Aijun Liao, Liu Yuan, Ying He, Xiaogang Chen and Zongchang Li.

Publication date: December 9, 2024.

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The involvement of the microbiota-gut-brain axis in the pathophysiology of mood disorders and therapeutic implications

Researchers involved: Izabela G Barbosa, Aline S. Miranda, Michael Berk and Antonio L Teixeira.

Publication date: December 8, 2024.

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Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways

Researchers involved: Xiaolu Zhang, Jake Valeri, Mahmoud A Eladawi, Barbara Gisabella, Michael R Garrett, Eric J Vallender, Robert McCullumsmith, Harry Pantazopoulos and Sinead M O’Donovan.

Publication date: November 11, 2024.

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Neuroinflammation, Stress-Related Suicidal Ideation, and Negative Mood in Depression

Researchers involved: Sarah Herzog, Elizabeth A. Bartlett, Francesca Zanderigo, Hanga C. Galfalvy, Ainsley Burke, Akiva Mintz, Mike Schmidt, Eric Hauser, Yung-yu Huang, Nadine Melhem, Elizabeth Sublette, Jeffrey M. Miller and J. John Mann.

Publication date: November 6, 2024.

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Claudin-5 and occludin levels in patients with psychiatric disorders

Researchers involved: Zinovia Maridaki, Georgios Syrros, Stella Gianna Delichatsiou, Jerry Warsh, Gerasimos and N. Konstantinou.

Publication date: November 3, 2024.

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Unraveling the role of the renin-angiotensin system in severe mental illnesses

An insight into psychopathology and cognitive deficits.

Researchers involved: Aline Silva de Miranda, Danielle S. Macedo, Lia Lira O. Sanders, Aline S. Monte, Michelle Verde Ramo Soares and Antonio Lucio Teixeira.

Publication date: September 19, 2024.

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The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking

Researchers involved: Rhushikesh A. Phadke, Alison Brack, Luke A. Fournier, Ezra Kruzich, Mingqi Sha, Ines Picard, Connor Johnson, Dimitri Stroumbakis, Maria Salgado, Charlotte Yeung, Berta Escude Velasco, Yen Yu Liu and Alberto Cruz-Martín.

Publication date: September 3, 2024.

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