Publications in precision psychiatry

Mental Disorders as a Risk Factor of Acute Coronary Syndrome

A Systematic Review and Meta-Analysis.

Researchers involved: Arnav Gupta, Tushar Tejpal, Chanhee Seo, Nicholas Fabiano, Selina Zhao, Stanley Wong, Yuan Qiu, Jenna MacNeil, Dain R Kim, Natasha Aleksova, Sara Siddiqi, Marco Solmi and Jess G Fiedorowicz.

Publication date: March 1, 2026.

Find out more here.

Brain and Blood Biomarkers of Major Depressive Disorder

A Systematic Review.

Researchers involved: Lia J. Zallar and Maura B. Dupont.

Publication date: January 25, 2026.

Find out more here.

Pharmacogenomics of response to treatment with antiepileptic drugs and mood stabilizers in bipolar disorder

A study by the MoStGen consortium.

Researchers involved: Ada Man-Choi Ho, Brandon J. Coombes, Anthony Batzler, Vanessa K. Pazdernik, Richard S. Pendegraft, Michelle Skime, Narjes Bendjemaa, Bernardo Carpiniello, Martina Contu, Nina Dalkner, Frederike T. Fellendorf, Giovanna Fico, Claudio D. Fullerton, Manuel Gardea-Resendez, Sarai Gonzalez-Garza, Nematollah Jaafari, Esther Jiménez, Oussama Kebir, Adrien Legrand, Sofia Luna-Garza, Anna Meloni, Bruno Millet, Fayçal Mouaffak, Abraham Nunes, Claire O’Donovan, Pasquale Paribello, Marco Pinna, Claudia Pisanu, Edith Pomarol-Clotet, Francisco Romo-Nava, Raúl F. Sánchez, Katie Scott, Alessio Squassina, Elisabet Vilella, Alessandro Serretti, Miguel L. Prieto, Eva Z. Reininghaus, Susanne A. Bengesser, Alfredo B. Cuellar-Barboza, Marie-Odile Krebs, Boris Chaumette, Eduard Vieta, Mirko Manchia, Susan L. McElroy, Martin Alda, Mark A. Frye and Joanna M. Biernacka.

Publication date: January 19, 2026.

Find out more here.

Long-term exposure to air pollution and mental health in French adults from the CONSTANCES cohort

Role of black carbon independently of PM2.5.

Researchers involved: Zeinab Bitar, Baptiste Pignon, Cédric Lemogne, Kees de Hoogh, Marcel Goldberg, Franck Schürhoff, Danielle Vienneau, Mohammad Javad Zare Sakhvidi, Marie Zins, Emeline Lequy, Emilie Burte and Bénédicte Jacquemin.

Publication date: January 6, 2026.

Find out more here.

Exploring temperamental and clinical predictors of lithium treatment outcomes in bipolar disorder using diverse machine learning approaches

Researchers involved: Alessandro Miola, Michele Fornaro, Valeria Di Stefano, Ilaria Pullano, Francesco Monaco and Luca Steardo.

Publication date: January 6, 2026.

Find out more here.

Targeting Inflammation: How Meta-Analysis Can Advance Precision Psychiatry

Researchers involved: Femke Lamers, Ph.D.

Publication date: January 1, 2026.

Find out more here.

Gut microbiota mediated neuroinflammation in psychiatric disorders

Current perspectives and challenges.

Researchers involved: Anushka Nayak, Suranjana Bera, Samprikta Purohit and Chakresh Kumar Jain.

Publication date: December 29, 2025.

Find out more here.

Purinergic signaling and energetic metabolism in bipolar disorder

From pathophysiology to precision therapeutics.

Researchers involved: Magda Malewska-Kasprzak, Monika Dmitrzak-Weglarz and Filip Rybakowski.

Publication date: December 22, 2025.

Find out more here.

Inflammation, metabolic dysregulation, and depression profiles related to anhedonia and atypical, energy-related symptoms

Researchers involved: J.C. Zwiep, F. Lamers, C.H. Vinkers, N.J.A. van der Wee, , B.W.J.H. Penninx, L. Nawijn, Y. Milaneschi.

Publication date: December 22, 2025.

Find out more here.

Implementation of precision medicine in psychiatry

Researchers involved: Federico Cevoli, Husseini K. Manji, Andrew H. Miller, Brenda W. J. H. Penninx, Martien Kas, Carmine Pariante, Livia De Picker, Pawel Swieboda and Marion Leboyer.

Publication date: December 10, 2025.

Find out more here.

Mapping the genetic landscape of 14 psychiatric disorders

Researchers involved: Andrew D Grotzinger, Josefin Werme, Wouter J Peyrot, Oleksandr Frei, Christiaan de Leeuw, Lucy K Bicks, Qiuyu Guo, Michael P Margolis, Brandon J Coombes, Anthony Batzler, Vanessa Pazdernik, Joanna M Biernacka, Ole A Andreassen, Verneri Anttila, Anders D Børglum, Gerome Breen, Na Cai, Ditte Demontis, Howard J Edenberg, Stephen V Faraone, Barbara Franke, Michael J Gandal, Joel Gelernter, Alexander S Hatoum, John M Hettema, Emma C Johnson, Katherine G Jonas, James A Knowles, Karestan C Koenen, Adam X Maihofer, Travis T Mallard, Manuel Mattheisen, Karen S Mitchell, Benjamin M Neale, Caroline M Nievergelt, John I Nurnberger, Kevin S O’Connell, Roseann E Peterson, Elise B Robinson, Sandra S Sanchez-Roige, Susan L Santangelo, Jeremiah M Scharf, Hreinn Stefansson, Kari Stefansson, Murray B Stein, Nora I Strom, Laura M Thornton, Elliot M Tucker-Drob, Brad Verhulst, Irwin D Waldman, G Bragi Walters, Naomi R Wray, Dongmei Yu, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium, Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nicotine Dependence GenOmics (iNDiGO) Consortium, Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Phil H Lee, Kenneth S Kendler and Jordan W Smoller.

Publication date: December 10, 2025.

Find out more here.

Role of Genetic and Epigenetic Biomarkers in Treatment-Resistant Depression

A Literature Review.

Researchers involved: Petra Sulić, Andrea Ražić Pavičić, Biljana Đapić Ivančić, Tamara Božina, Nada Božina and Maja Živković.

Publication date: December 2, 2025.

Find out more here.

Wearable organic-electrochemical-transistor-based lithium sensor for precision mental health

Researchers involved: Mohammad Shafiqul Islam, Brince Paul Kunnel, Munia Ferdoushi, Md Farhad Hassan, Sangwon Cha, Wenxin Cai, Adam Frank and Yasser Khan.

Publication date: July 18, 2025.

Find out more here.

Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression

Researchers involved: John R. Shorter, Joëlle A. Pasman, Siim Kurvits, Andreas Jangmo, Joonas Naamanka, Arvid Harder, Espen Hagen, Kaarina Kowalec, Nelli Frilander, Richard Zetterberg, Joeri J. Meijsen, Jesper R. Gådin, Jacob Bergstedt, Ying Xiong, Sara Hägg, Mikael Landén, Christian Rück, John Wallert, Alkistis Skalkidou, Elise Koch, Bayram C. Akdeniz, Oleksandr Frei, FinnGen, Iiris Hovatta, Ted Reichborn-Kjennerud, Thomas M. Werge, Patrick F. Sullivan, Ole A. Andreassen, Martin Tesli, Kelli Lehto, Alfonso Buil and Yi Lu.

Publication date: November 13, 2025.

Find out more here.

Socio-demographic and clinical factors show no clear association with patient-reported rehabilitation outcomes in schizophrenia

Researchers involved: Guillaume Barbalat, Julien Plasse, Isabelle Chéreau-Boudet, Benjamin Gouache, Emilie Legros-Lafarge, Nathalie Guillard-Bouhet and Nicolas Franck.

Publication date: November 7, 2025.

Find out more here.

The effects of antidepressants on cardiometabolic and other physiological parameters

A systematic review and network meta-analysis.

Researchers involved: Toby Pillinger, Atheeshaan Arumuham, Robert A. McCutcheon, Enrico D’Ambrosio, Georgios Basdanis, Marco Branco, Richard Carr, Valeria Finelli, Toshi A. Furukawa, Siobhan Gee, Adrian Heald, Sameer Jauhar, Zihan Ma, Valentina Mancini, Calum Moulton, Georgia Salanti, David M. Taylor, Anneka Tomlinson, Allan H. Young, Orestis Efthimiou, Oliver D. Howes and Andrea Cipriani.

Publication date: October 21, 2025.

Find out more here.

Anti-inflammatory drugs for treating depression: challenges and ASPIRations

Researchers involved: Courtney Worrell, Bernhard T Baune, Francesco Benedetti, Annamaria Cattaneo, Livia De Picker, Jennifer C Felger, Stefan M Gold, Femke Lamers, Marion Leboyer, Giulia Lombardo, Fanni-Laura Mäntylä, Andrew H Miller, Valeria Mondelli, Brenda W J H Penninx, Luca Sforzini, Dan J Stein, Benedetta Vai, Erik Van der Eycken, Anthony Woods and Carmine M Pariante.

Publication date: October 17, 2025.

Find out more here.

Polygene risk scores for severe psychiatric disorders in bipolar disorder

Associations with clinical and dimensional expression, interactions with child maltreatment, and mediation models.

Researchers involved: Bruno Etain, Mohamed Lajnef, Ophélia Godin, Cynthia Marie-Claire, Frank Bellivier, Elisa Courtois, Violaine Latapie, Sébastien Gard, Raoul Belzeaux, Philippe Courtet, Caroline Dubertret, Emmanuel Haffen, Antoine Lefrere, Emilie Olie, Mircea Polosan, Paul Roux, Ludovic Samalin, Raymund Schwan, Marion Leboyer and Stéphane Jamain on behalf of the staff at the FondaMental Expert Centers for Bipolar Disorders (FACE-BD).

Publication date: July 25, 2025.

Find out more here.

Staging of suicidality in bipolar disorder

Results from the FACE-BD cohort (FondaMental Expert Center for Bipolar Disorders).

Researchers involved: Anna Maria Auxilia, Emilie Olié, Jonathan Dubois, Enrico Capuzzi, Valérie Aubin, Bruno Aouizerate, Frank Bellivier, Raoul Belzeaux, Caroline Dubertret, Dominique Januel, Emmanuel Haffen, Antoine Lefrere, Agnès Pelletier, Mircea Polosan, Roman Rey, Paul Roux, Ludovic Samalin, Raymund Schwan, Michel Walter, Antoine Yrondi; FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators; Pierre Michel Llorca, Marion Leboyer, Bruno Etain and Philippe Courtet.

Publication date: July 22, 2025.

Find out more here.

Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity

Researchers involved: Tracey van der Veen, Markos Tesfaye, Jessica Mei Kay Yang, Toni Boltz, Friederike S David, Shane Crinion, Maria Koromina, Till F M Andlauer, Tim B Bigdeli, Brandon J Coombes, Tiffany A Greenwood, Georgia Panagiotaropoulou, Nadine Parker, Heejong Sung, Nicholas Bass, Jonathan R I Coleman, José Guzman-Parra, Janos L Kalman, Caroline C McGrouther, Brittany L Mitchell, Aaditya V Rangan, Katie Scott, Alexey Shadrin, Daniel J Smith, Annabel Vreeker, Kristina Adorjan, Diego Albani, Silvia Alemany, Ney Alliey-Rodriguez, Anastasia Antoniou, Michael Bauer, Eva C Beins, Marco P Boks, Rosa Bosch, Ben M Brumpton, Nathalie Brunkhorst-Kanaan, Monika Budde, William Byerley, Judit Cabana-Domínguez, Murray J Cairns, Bernardo Carpiniello, Miquel Casas, Pablo Cervantes, Chris Chatzinakos, Toni-Kim Clarke, Isabelle Claus, Cristiana Cruceanu, Alfredo Cuellar-Barboza, Piotr M Czerski, Konstantinos Dafnas, Anders M Dale, Nina Dalkner, J Raymond DePaulo, Franziska Degenhardt, Srdjan Djurovic, Valentina Escott-Price, Ayman H Fanous, Frederike T Fellendorf, I Nicol Ferrier, Liz Forty, Josef Frank, Oleksandr Frei, Nelson B Freimer, Julie Garnham, Ian R Gizer, Scott D Gordon, Katherine Gordon-Smith, Tim Hahn, L Marian, Arvid Harder, Martin Hautzinger, Urs Heilbronner, Dennis Hellgren, Stefan Herms, Ian B Hickie, Per Hoffmann, Peter A Holmans, Stéphane Jamain, Lina Jonsson, James L Kennedy, Sarah Kittel-Schneider, James A Knowles, Elise Koch, Manolis Kogevinas, Thorsten M Kranz, Steven A Kushner, Catharina Lavebratt, Jacob Lawrence, Markus Leber, Penelope A Lind, Susanne Lucae, Martin Lundberg, Donald J MacIntyre, Wolfgang Maier, Adam X Maihofer, Dolores Malaspina, Mirko Manchia, Eirini Maratou, Lina Martinsson, Melvin G McInnis, James D McKay, Helena Medeiros, Andreas Meyer-Lindenberg, Vincent Millischer, Derek W Morris, Paraskevi Moutsatsou, Thomas W Mühleisen, Claire O ‘Donovan, Catherine M Olsen, Sergi Papiol, Antonio F Pardiñas, Amy Perry, Andrea Pfennig, Claudia Pisanu, James B Potash, Digby Quested, Mark H Rapaport, Eline J Regeer, John P Rice, Margarita Rivera, Eva C Schulte, Fanny Senner, Paul D Shilling, Lisa Sindermann, Lea Sirignano, Dan Siskind, Claire Slaney, Olav B Smeland, Janet L Sobell, Maria Soler Artigas, Dan J Stein, Frederike Stein, Beata Swiatkowska, Jackson G Thorp, Claudio Toma, Leonardo Tondo, Paul A Tooney, Marquis P Vawter, Helmut Vedder, James T R Walters, Stephanie H Witt, Allan H Young, Peter P Zandi, Lea Zillich; Estonian Biobank research team; Genomic Psychiatry Cohort (GPC) Investigators; HUNT All-In Psychiatry; Rolf Adolfsson, Lars Alfredsson, Lena Backlund, Bernhard T Baune, Frank Bellivier, Susanne Bengesser, Wade H Berrettini, Joanna M Biernacka, Douglas Blackwood, Michael Boehnke, Gerome Breen, Vaughan J Carr, Stanley Catts, Sven Cichon, Aiden Corvin, Nicholas Craddock, Udo Dannlowski, Dimitris Dikeos, Tõnu Esko, Bruno Etain, Panagiotis Ferentinos, Mark Frye, Janice M Fullerton, Micha Gawlik, Elliot S Gershon, Fernando S Goes, Melissa J Green, Joanna Hauser, Frans A Henskens, Jens Hjerling-Leffler, Ian Jones, Lisa A Jones, René S Kahn, John R Kelsoe, Tilo Kircher, George Kirov, Nene Kobayashi, Mikael Landén, Marion Leboyer, Melanie Lenger, Qingqin S Li, Jolanta Lissowska, Carmel Loughland, Jurjen J Luykx, Nicholas G Martin, Carol A Mathews, Fermin Mayoral, Susan L McElroy, Andrew M McIntosh, Sarah E Medland, Ingrid Melle, Philip B Mitchell, Gunnar Morken, Richard M Myers, Chiara Möser, Bertram Müller-Myhsok, Benjamin M Neale, Caroline M Nievergelt, John I Nurnberger, Markus M Nöthen, Michael C O’Donovan, Ketil J Oedegaard, Tomas Olsson, Michael J Owen, Sara A Paciga, Christos Pantelis, Carlos N Pato, Michele T Pato, George P Patrinos, Joanna M Pawlak, Roy Perlis, Josep Antoni Ramos-Quiroga, Andreas Reif, Eva Z Reininghaus, Marta Ribasés, Marcella Rietschel, Stephan Ripke, Guy A Rouleau, Ulrich Schall, Martin Schalling, Peter R Schofield, Thomas G Schulze, Laura J Scott, Rodney J Scott, Alessandro Serretti, Jordan W Smoller, Alessio Squassina, Eli A Stahl, Eystein Stordal, Fabian Streit, Patrick F Sullivan, Gustavo Turecki, Arne E Vaaler, Eduard Vieta, John B Vincent, Irwin D Waldman, Cynthia S Weickert, Thomas W Weickert, David C Whiteman, Martin Alda, Roel A Ophoff, Kevin S O’Connell, Niamh Mullins, Andreas J Forstner, Maria Grigoroiu-Serbanescu, Howard J Edenberg, Francis J McMahon, Ole A Andreassen, Arianna Di Florio, Andrew McQuillin and Bipolar Disorder Working Group of the Psychiatric Genomics Consortium.

Publication date: June 25, 2025.

Find out more here.

Fine-mapping genomic loci refines bipolar disorder risk genes

Researchers involved: Maria Koromina, Ashvin Ravi, Georgia Panagiotaropoulou, Brian M Schilder, Jack Humphrey, Alice Braun, Tim Bidgeli, Chris Chatzinakos, Brandon J Coombes, Jaeyoung Kim, Xiaoxi Liu, Chikashi Terao, Kevin S O’Connell, Mark J Adams, Rolf Adolfsson, Martin Alda, Lars Alfredsson, Till F M Andlauer, Ole A Andreassen, Anastasia Antoniou, Bernhard T Baune, Susanne Bengesser, Joanna Biernacka, Michael Boehnke, Rosa Bosch, Murray J Cairns, Vaughan J Carr, Miquel Casas, Stanley Catts, Sven Cichon, Aiden Corvin, Nicholas Craddock, Konstantinos Dafnas, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Arianna Di Florio, Dimitris Dikeos, Frederike Tabea Fellendorf, Panagiotis Ferentinos, Andreas J Forstner, Liz Forty, Mark Frye, Janice M Fullerton, Micha Gawlik, Ian R Gizer, Katherine Gordon-Smith, Melissa J Green, Maria Grigoroiu-Serbanescu, José Guzman-Parra, Tim Hahn, Frans Henskens, Jan Hillert, Assen V Jablensky, Lisa Jones, Ian Jones, Lina Jonsson, John R Kelsoe, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Manolis Kogevinas, Mikael Landén, Marion Leboyer, Melanie Lenger, Jolanta Lissowska, Christine Lochner, Carmel Loughland, Donald J MacIntyre, Nicholas G Martin, Eirini Maratou, Carol A Mathews, Fermin Mayoral, Susan L McElroy, Nathaniel W McGregor, Andrew McIntosh, Andrew McQuillin, Patricia Michie, Philip B Mitchell, Paraskevi Moutsatsou, Bryan Mowry, Bertram Müller-Myhsok, Richard M Myers, Igor Nenadić, Caroline M Nievergelt, Markus M Nöthen, John Nurnberger, Michael O ‘Donovan, Claire O ‘Donovan, Roel A Ophoff, Michael J Owen, Christos Pantelis, Carlos Pato, Michele T Pato, George P Patrinos, Joanna M Pawlak, Roy H Perlis, Evgenia Porichi, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Andreas Reif, Eva Z Reininghaus, Marta Ribasés, Marcella Rietschel, Ulrich Schall, Peter R Schofield, Thomas G Schulze, Laura Scott, Rodney J Scott, Alessandro Serretti, Jordan W Smoller, Beata Świątkowska, Maria Soler Artigas, Dan J Stein, Fabian Streit, Claudio Toma, Paul Tooney, Marquis P Vawter, Eduard Vieta, John B Vincent, Irwin D Waldman, Cynthia Shannon Weickert, Thomas Weickert, Stephanie H Witt, Kyung Sue Hong, Masashi Ikeda, Nakao Iwata, Hong-Hee Won, Howard J Edenberg, Stephan Ripke, Towfique Raj, Jonathan R I Coleman and Niamh Mullins.

Publication date: June 25, 2025.

Find out more here.

Vascular homeostasis in suicidal behavior

From molecular mechanisms to clinical implications.

Researchers involved: Aiste Lengvenyte and Philippe Courtet.

Publication date: June 22, 2025.

Find out more here.

Clinical and inflammatory markers associated with fatty liver disease associated with metabolic dysfunction in a cohort of individuals with chronic schizophrenia (FACE-SZ)

Researchers involved: Rudy Tokarski, Susana Barbosa, Baptiste Pignon, Bruno Aouizerate, Christelle Andrieu, Myrtille Andre, Wahid Boukouaci, Delphine Capdevielle, Isabelle Chereau, Clément Dondé, Julie Clauss Kobayashi, J M Dorey, Caroline Dubertret, Eric Fakra, Guillaume Fond, Tudy Goze, Sylvain Leignier, Pierre-Michel Llorca, Jasmina Mallet, David Misdrahi, Nicolas Oriol, Romain Rey, Paul Roux, Franck Schürhoff, Benoit Schorr, Andrei Szöke, Mathieu Urbach, Etienne Very, Ching-Li Wu, FACE-SZ group, Marion Leboyer, Ryad Tamouza and Ophelia Godin.

Publication date: June 22, 2025.

Find out more here.

Precision Psychiatry Roadmap

Towards a biology-based framework for mental disorders.

Researchers involved: Martien J. H. Kas, Brenda W. J. H. Penninx, Gitte M. Knudsen, Bruce Cuthbert, Peter Falkai, Gary S. Sachs, Kerry J. Ressler, Ewa Bałkowiec-Iskra, Florence Butlen-Ducuing, Marion Leboyer, Hugh Marston, Johan Luthman and Valentina Mantua.

Publication date: June 19, 2025.

Find out more here.

Substance use disorders in outpatients with bipolar disorder and pain

Researchers involved: J Chabert, R Icick, J Cabé, X Moisset, O Godin, S Gard, B Aouizerate, J Loftus, V Aubin, A Lefrere, C Dubertret, P Roux, M Polosan, T Schwitzer, B Etain, R Moirand, E Olié, E Haffen, M Leboyer, P Courtet, M Walter, N Bouaziz, A Yrondi, R Belzeaux, Bipolar-Addiction workgroup, FACE-BD collaborators, P M Llorca, G Brousse and L Samalin.

Publication date: June 18, 2025.

Find out more here.

Disease severity across psychiatric disorders is linked to pro-inflammatory cytokines

Researchers involved: Pierre Solomon, Monika Budde, Mojtaba Oraki Kohshour, Kristina Adorjan, Maria Heilbronner, Alba Navarro-Flores, Sergi Papiol, Daniela Reich-Erkelenz, Eva C. Schulte, Fanny Senner, Thomas Vogl, Lalit Kaurani, Dennis M. Krüger, Farahnaz Sananbenesi, Tonatiuh Pena, Susanne Burkhardt, Anna-Lena Schütz, Ion-George Anghelescu, Volker Arolt, Bernhardt T. Baune, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Christian Figge, Georg Juckel, Carsten Konrad, Fabian U. Lang, Jens Reimer, Eva Z. Reininghaus, Max Schmauß, Carsten Spitzer, Jens Wiltfang, Jörg Zimmermann, André Fischer, Peter Falkai, Thomas G. Schulze, Urs Heilbronner and Jeremie Poschmann.

Publication date: June 10, 2025.

Find out more here.

Genomics of schizophrenia, bipolar disorder and major depressive disorder

Researchers involved: Michael J. Owen, Nicholas J. Bray, James T. R. Walters and Michael C. O’Donovan.

Publication date: May 12, 2025.

Find out more here.

Towards precision and personalized treatment strategies in psychiatry

Researchers involved: Stefano Comai, Mirko Manchia, Marta Bosia, Alessandro Miola, Sara Poletti, Francesco Benedetti, Sofia Nasini, Raffaele Ferri, Dan Rujescu, Marion Leboyer, Julio Licinio, Bernhard T Baune and Alessandro Serretti.

Publication date: April 21, 2025.

Find out more here.

Bioenergetic biomarkers as predictive indicators and their relationship to cognitive function

In newly diagnosed, treatment-naïve patients with bipolar disorder.

Researchers involved: Ting Cao, BAoYan Xu, SuJuan Li, Yan Qiu, JinDong Chen, HaiShan Wu and HaLin Cai.

Publication date: April 14, 2025.

Find out more here.

Telomerase activity and telomere homeostasis in major depressive disorder, schizophrenia, and bipolar disorder

A systematic review.

Researchers involved: Johanna Thurin, Bruno Etain, Frank Bellivier and Cynthia Marie-Claire.

Publication date: April 13, 2025.

Find out more here.

Variability rather than average?

Exploiting the adversary to advance precision psychiatry.

Researchers involved: Raquel E. Gur, David R. Roalf, Daniel H. Wolf and Ruben C. Gur.

Publication date: April 1, 2025.

Find out more here.

How metacognition affects the quality of life of people with schizophrenia

Structural equation modeling with the Face-Sz cohort.

Researchers involved: Solène Frileux, Nathan Faivre, Mathieu Urbach, Nathan Vidal, Hugo Bottemanne, Fabrice Berna, Cristobal Belmonte, Laurent Boyer, Delphine Capdevielle, Julie Clauss, Isabelle Chéreau, Thierry d’Amato, Caroline Dubertret, Julien Dubreucq, Guillaume Fond, Sylvain Leigner, Pierre-Michel Llorca, Jasmina Mallet, David Misdrahi, Baptiste Pignon, Romain Rey, Franck Schürhoff, Arnaud Tessier, Christine Passerieux, Eric Brunet-Gouet and Paul Roux.

Publication date: March 22, 2025.

Find out more here.

Let's move towards precision suicidology

Researchers involved: Philippe Courtet and P.A Saiz.

Publication date: March 18, 2025.

Find out more here.

Circulating blood proteins in psychopathology and cognition

A Mendelian randomization study.

Researchers involved: Upasana Bhattacharyya, Jibin John, Max Lam, Jonah Fisher, Benjamin Sun, Denis Baird, Stephen Burgess, Chia-Yen Chen and Todd Lencz.

Publication date: March 12, 2025.

Find out more here.

Metabolic syndrome and schizophrenia

Adding a piece to the interaction between the kynurenine pathway and inflammation.

Researchers involved: Jacopo Sapienza, Giulia Agostoni, Federica Repaci, Marco Spangaro, Stefano Comai and Marta Bosia.

Publication date: March 5, 2025.

Find out more here.

An anxious generation in France

How the pandemic has confirmed and amplified the vulnerabilities of young people.

Researchers involved: Laurent Boyer, Pierre-Michel Llorca, Dong Keon Yon, Bach Tran, Vanessa Pauly, Bastien Boussat and Guillaume Fond.

Publication date: March 2, 2025.

Find out more here.

Neurofind: using deep learning to make individualized inferences in brain disorders

Researchers involved: S. Vieira, L. Baecker, W. H. L. Pinaya, R. Garcia-Dias, C. Scarpazza, V. Calhoun and A. Mechelli.

Publication date: February 27, 2025.

Find out more here.

Predicting relapse in a French cohort of outpatients with schizophrenia

Prediction, not association.

Researchers involved: Susana Barbosa, Ryad Tamouza, Marion Leboyer, Bruno Aouizerate, Christelle Andrieu, Myrtille Andre, Wahid Boukouaci, Delphine Capdevielle, Isabelle Chereau, Julie Clauss Kobayashi, Nathalie Coulon, Jean-Michel Dorey, Laetitia Davidovic, Caroline Dubertret, Eric Fakra, Guillaume Fond, Tudi Goze, Olfa Khalfallah, Sylvain Leignier, Pierre Michel Llorca, Jasmina Mallet, Emanuela Martinuzzi, David Misdrahi, Nicolas Oriol, Baptiste Pignon, Romain Rey, Paul Roux, Franck Schürhoff, Benoit Schorr, Mathieu Urbach, Etienne Very, Ching-Lien Wu, Michael Benros, Judit Simon, Alkomiet Hasan, The FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) collaborators, Nicolas Glaichenhaus and Ophélia Godin.

Publication date: February 27, 2025.

Find out more here.

Genetic correlates of treatment-resistant depression

Researchers involved: Bohan Xu, Katherine L. Forthman, Rayus Kuplicki, Jonathan Ahern, Robert Loughnan, Firas Naber, Wesley K. Thompson, Charles B. Nemeroff, Martin P. Paulus and Chun Chieh Fan.

Publication date: February 26, 2025.

Find out more here.

Oxidative and nitrosative stress in bipolar disorder and its familial aggregation

Researchers involved: Singh Harpreet, Singh Abhishek K, Kar, Sujita K, Tripathi Adarsh, Dalal Pronob K and Dikshit Madhu.

Publication date: February 2025.

Find out more here.

Prediction of available drug targets and common genetic links in bipolar disorder and major depressive disorder

Researchers involved: Bin Gong, Chenxu Xiao, Yu Feng and Jing Shen.

Publication date: January 30, 2025.

Find out more here.

Genomics yields biological and phenotypic insights into bipolar disorder

Researchers and centers involved: Kevin S. O’Connell, Maria Koromina, Tracey van der Veen, Toni Boltz, Friederike S. David, Jessica Mei Kay Yang, Keng-Han Lin, Xin Wang, Jonathan R. I. Coleman, Brittany L. Mitchell, Caroline C. McGrouther, Aaditya V. Rangan, Penelope A. Lind, Elise Koch, Arvid Harder, Nadine Parker, Jaroslav Bendl, Kristina Adorjan, Esben Agerbo, Diego Albani, Silvia Alemany, Ney Alliey-Rodriguez, Thomas D. Als, Till F. M. Andlauer, 23andMe Research Team and Bipolar Disorder Working Group of the Psychiatric Genomics Consortium.

Publication date: January 22, 2025.

Find out more here.

Advancing precision psychiatry and targeted treatments

Prospects for immunopsychiatry.

Researchers and centers involved: Andrew H. Miller, Michael Berk, Gilles Bloch, Veronique Briquet-Laugier, Carinne Brouillon, Bruce N. Cuthbert, Robert Dantzer, Michael C. Davis, Livia J. De Picker, Wayne C. Drevets, Harris A. Eyre, Laura M. Hack, Neil A. Harrison, Andrew D. Krystal, Giulia Lombardo, Valeria Mondelli, Carmine M. Pariante, Luigi Pulvirenti, Giacomo Salvadore, Luca Sforzini, Pawel Swieboda, Madhukar H. Trivedi and Marion Leboyer.

Publication date: January 17, 2025.

Find out more here.

The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric 5 Disorders

Researchers and centers involved: Andrew D Grotzinger, Josefin Werme, Wouter J Peyrot, Oleksandr Frei, Christiaan de Leeuw, Lucy K Bicks, Qiuyu Guo, Michael P Margolis, Brandon J Coombes, Anthony Batzler, Vanessa Pazdernik, Joanna M Biernacka, Ole A Andreassen, Verneri Anttila, Anders D Børglum, Na Cai, Ditte Demontis, Howard J Edenberg, Stephen V Faraone, Barbara Franke, Michael J Gandal, Joel Gelernter, John M Hettema, Katherine G Jonas, James A Knowles, Karestan C Koenen, Adam X Maihofer, Travis T Mallard, Manuel Mattheisen, Karen S Mitchell, Benjamin M Neale, Caroline M Nievergelt, John I Nurnberger, Kevin S O’Connell, Elise B Robinson, Sandra S Sanchez-Roige, Susan L Santangelo, Hreinn Stefansson, Kari Stefansson, Murray B Stein, Nora I Strom, Laura M Thornton, Elliot M Tucker-Drob, Brad Verhulst, Irwin D Waldman, G Bragi Walters, Naomi R Wray, Anxiety Disorders Working Group, Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group, Autism Spectrum Disorders Working Group, Bipolar Disorder Working Group, Eating Disorders Working Group, Major Depressive Disorder Working Group, Nicotine Dependence GenOmics (iNDiGO) Consortium, Obsessive-Compulsive Disorder Working Group, Post-Traumatic Stress Disorder Working Group, Schizophrenia Working Group, Substance Use Disorders Working Group, Tourette Syndrome Working Group, Phil H Lee, Kenneth S Kendler and Jordan W Smoller.

Publication date: January 15, 2025.

Find out more here.

Precision psychiatry : thinking beyond simple prediction models

Enhancing causal predictions.

Researchers involved: Rajeev Krishnadas, Samuel P. Leighton and Peter B. Jones.

Publication date: January 15, 2025.

Find out more here.

A multimodal neural signature of face processing in autism within the fusiform gyrus

Investigators involved: Dorothea L Floris, Alberto Llera, Mariam Zabihi, Carolin Moessnang, Emily J H Jones, Luke Mason, Rianne Haartsen, Nathalie E Holz, Ting Mei, Camille Elleaume, Bruno Hebling Vieira, Charlotte M Pretzsch, Natalie J Forde, Sarah Baumeister, Flavio Dell’Acqua, Sarah Durston, Tobias Banaschewski, Christine Ecker, Rosemary J Holt, Simon Baron-Cohen, Thomas Bourgeron, Tony Charman, Eva Loth, Declan G M Murphy, Jan K Buitelaar, Christian F Beckmann, EU–AIMS LEAP group and Nicolas Langer.

Publication date: January 2, 2025.

Find out more here.

Assessment and ascertainment in psychiatric molecular genetics

Challenges and opportunities for cross-disorder research.

Researchers involved: Na Cai, Brad Verhulst, Ole A. Andreassen, Jan Buitelaar, Howard J. Edenberg, John M. Hettema, Michael Gandal, Andrew Grotzinger, Katherine Jonas, Phil Lee, Travis T. Mallard, Manuel Mattheisen, Michael C. Neale, John I. Nurnberger Jr, Wouter J. Peyrot, Elliot M. Tucker-Drob, Jordan W. Smoller and Kenneth S. Kendler.

Publication date: December 27, 2024.

Find out more here.

A stratified treatment algorithm in psychiatry

A program on stratified pharmacogenomics in severe mental illness (Psych-STRATA) : concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe.

Researchers involved: B. T. Baune, S. E. Fromme, M. Aberg, M. Adli, A. Afantitis, I. Akkouh, O. A. Andreassen, C. Angulo, S. Barlati, C. Brasso, P. Bucci, M. Budde, P. Buspavanich, V. Cavone, K. Demyttenaere, C. M. Diaz-Caneja, M. Dierssen, S. Djurovic, M. Driessen, U. W. Ebner-Priemer, J. Engelmann, S. Englisch, C. Fabbri, P. Fossati and M. J. Zille.

Publication date: December 27, 2024.

Find out more here.

The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders

A Two-Step Mendelian Randomization Analysis.

Researchers involved: Linlin Zhao, Liwen Tan, Weiqing Liu, Sijie Zhang, Aijun Liao, Liu Yuan, Ying He, Xiaogang Chen and Zongchang Li.

Publication date: December 9, 2024.

Find out more here.

The involvement of the microbiota-gut-brain axis in the pathophysiology of mood disorders and therapeutic implications

Researchers involved: Izabela G Barbosa, Aline S. Miranda, Michael Berk and Antonio L Teixeira.

Publication date: December 8, 2024.

Find out more here.

Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways

Researchers involved: Xiaolu Zhang, Jake Valeri, Mahmoud A Eladawi, Barbara Gisabella, Michael R Garrett, Eric J Vallender, Robert McCullumsmith, Harry Pantazopoulos and Sinead M O’Donovan.

Publication date: November 11, 2024.

Find out more here.

Neuroinflammation, Stress-Related Suicidal Ideation, and Negative Mood in Depression

Researchers involved: Sarah Herzog, Elizabeth A. Bartlett, Francesca Zanderigo, Hanga C. Galfalvy, Ainsley Burke, Akiva Mintz, Mike Schmidt, Eric Hauser, Yung-yu Huang, Nadine Melhem, Elizabeth Sublette, Jeffrey M. Miller and J. John Mann.

Publication date: November 6, 2024.

Find out more here.

Claudin-5 and occludin levels in patients with psychiatric disorders

Researchers involved: Zinovia Maridaki, Georgios Syrros, Stella Gianna Delichatsiou, Jerry Warsh, Gerasimos and N. Konstantinou.

Publication date: November 3, 2024.

Find out more here.

Unraveling the role of the renin-angiotensin system in severe mental illnesses

An insight into psychopathology and cognitive deficits.

Researchers involved: Aline Silva de Miranda, Danielle S. Macedo, Lia Lira O. Sanders, Aline S. Monte, Michelle Verde Ramo Soares and Antonio Lucio Teixeira.

Publication date: September 19, 2024.

Find out more here.

The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking

Researchers involved: Rhushikesh A. Phadke, Alison Brack, Luke A. Fournier, Ezra Kruzich, Mingqi Sha, Ines Picard, Connor Johnson, Dimitri Stroumbakis, Maria Salgado, Charlotte Yeung, Berta Escude Velasco, Yen Yu Liu and Alberto Cruz-Martín.

Publication date: September 3, 2024.

Find out more here.