Highlights from the 2026 PEPR PROPSY Annual Meeting – Day 1️⃣
April 1st at PariSanté Campus
The day opened with welcoming remarks by Marion Leboyer, followed by updates on calls for proposals presented by Marie-Hélène Soto and on France 2030 funding by Jean-Claude Dussaule.
The rest of the morning focused on the French Minds cohort, in a session chaired by Denis Vivien and Philippe Marin:
- Cohort protocol presented by Ophelia Godin
- Brain imaging protocol presented by Marie Chupin and Charles Laïdi
- Genetic analyses presented by Boris Chaumette and Jean-François Deleuze
Three projects were highlighted:
- PUMA, presented by Baptiste Pignon (pollution and mental health)
- Audicobe, presented by Ludovic Samalin and Ingrid de Chazeron (digital clinical trial)
- CIC-Psy, presented by Philippe Le Corvoisier (Clinical Investigation Centers)
The afternoon was dedicated to Work Package 5: information, training for researchers and healthcare professionals, and initiatives to enhance the field’s attractiveness.
This session was chaired by Arnaud Cachia:
- The Mood, presented by Coraline Hingray, focused on measuring and understanding patients’ emotional states to improve monitoring
- The early career scientists program, part of the EDU project, presented by Lucile Capuron and Florence Roullet, along with career development opportunities
- A presentation of work by winners of PEPR PROPSY project calls and fellowship calls
Congratulations to Jan Berkehan Erkilic, Lars Wilmes, Luana Spano, Claire Altersitz, Antoine Didier, Raphaël Vock, Taos Benoussaïd, Romain Hacquet, Yury Lages, Alexane Leclerc, Océane Dufrenne, Julie Chaudet, Julien Delages, Katia Chardon, and Lisa Pontoni!
Public-private partnerships serving patients were then presented through Work Package 4. This session, chaired by Pascal Mariotti, highlighted collaboration between research institutions, hospitals, and companies:
- The EEG-MIND project, presented by Aline Lefebvre, combining electrophysiology and artificial intelligence to better understand brain function
- The T4MIND project, presented by Laurent Boyer, placing patients at the center of psychiatric treatment evaluation
- The Patient Advisory Board (PAB), presented by Romain Rey, an initiative to strengthen direct patient involvement in the design and monitoring of research projects
The day concluded with a forward-looking discussion led by Franck Mouthon on the future of psychiatric research and its outlook toward 2030.
Highlights from the 2026 PEPR PROPSY Annual Meeting – Day 2️⃣
April 2nd at Inserm
This second day continued discussions on the impact of precision psychiatry and the transformations expected by 2030.
The morning opened with a presentation of the PEPR PROPSY International Scientific Advisory Board’s recommendations by Marion Leboyer, highlighting key challenges in structuring the program and its scientific ambitions.
The day was then organized around several major thematic sessions:
The issue of treatment resistance opened the discussions. This session, chaired by Lionel Da Cruz, featured a clinical perspective on definitions by Antoine Yrondi and an overview of associated pharmacological mechanisms by Boris Chaumette, illustrating the complexity of therapeutic pathways in psychiatry.
Discussions then turned to somatic comorbidities, addressing both their epidemiological impact, presented by Laurent Boyer, and advances in understanding underlying mechanisms and innovative care approaches, presented by Ophelia Godin. These exchanges emphasized the importance of an integrated approach to mental and physical health.
The afternoon continued with a session on the medico-economic impact of PEPR PROPSY innovations, presented by Isabelle Durand-Zaleski, highlighting key challenges related to evaluation and sustainability.
This was followed by a session on biomarkers supporting diagnosis and treatment, chaired by Etienne Thevenot: metabolomics with Ariel Frajerman, brain imaging with Charles Laïdi, and electrophysiology with Anton Iftimovici—illustrating the diversity of approaches within precision psychiatry.
The final session focused on reshaping psychiatric nosology in the context of precision psychiatry, chaired by Frank Bellivier.
Speakers highlighted several key dimensions:
- Impulsivity and suicidal behaviors, with Aiste Lengvenyte
- Cognitive flexibility, with Corentin Gosling
- Sensory abnormalities, with Anouck Amestoy
- Neurodevelopment, with Antoine Lefrere
- Sleep disorders, with Pierre Alexis Geoffroy
All of these contributions underscored the importance of rethinking diagnostic frameworks based on cross-cutting dimensions.
Overall, this second day showcased the richness of approaches in precision psychiatry, bridging fundamental research, clinical practice, and public health, in support of a sustainable transformation of psychiatric care. It also opened the door to new hypotheses and approaches that will be further developed within PEPR PROPSY.
